Prelude Therapeutics is a leading precision oncology company developing innovative medicines in areas of high unmet need for cancer patients. Our pipeline is comprised of several novel drug candidates including first-in-class, highly selective SMARCA2 and KAT6A degraders. We are also leveraging our expertise in targeted protein degradation to discover, develop and commercialize next generation degrader antibody conjugates (precision ADCs) with partners and advancing additional programs in discovery. We are on a mission to extend the promise of precision medicine to every cancer patient in need.
A Bold, Scientific Approach to the Discovery & Development of Innovative Medicines
The discovery of a new medicine is a complex journey of innovation, determination, and insight where both biology and chemistry orchestrate a potential solution for patients. At Prelude Therapeutics, we go where the science leads us, not constrained within a platform, or by a specific target class or chemical modality, to solve challenging, unmet needs of patients. We strive to turn our scientific insights into safe and effective drugs to improve the lives of people with cancer.
Take a look at what we have achieved and how we were able to do it »
KAT6 is an emerging, clinically validated target in the treatment of ER+ breast cancer and other solid tumors
Selective degradation of KAT6A has potential for improved efficacy and tolerability.
KAT6A
Precision
ADCs
CDK
inhibitors
SMARCA2
KAT6 is an emerging, clinically validated target in the treatment of ER+ breast cancer and other solid tumors
Selective degradation of KAT6A has potential for improved efficacy and tolerability.
Prelude and its partner AbCellera to develop potent degraders/inhibitors as payloads for novel antibodies targeting tumor specific antigens
Next generation ADCs to extend the therapeutic utility of this class.
Selective CDK9 and CDK4/6 inhibitors with potential application across a range of cancers now available for partnering.
SMARCA2 protein degraders designed to be synthetic lethal to SMARCA4 deletion that occur in a wide range of cancers
Potent and Selective Degrader
Potential to address major unmet need in biomarker-selected patients
Our Clinical Trials
Innovations in research and discovery, improved technologies, a deeper understanding of cancer biology and behavior, and novel scientific approaches are providing new hope for patients. The Prelude team is proud to have advanced several transformational cancer therapies for patients and we are rapidly moving additional novel therapeutics into clinical trials.
Our Team
With multiple, diverse first/best-in-class programs already in the clinic, we feel the urgency of applying our team’s expertise to finding the therapies that transform patients’ lives. Our cause is cancer, our purpose is patients, and we strive to develop safe, effective, and durable treatments to help improve patients’ lives.
Press Releases
May 6, 2025
Prelude Therapeutics Reports First Quarter 2025 Financial Results and Provides Corporate Update
Highly Selective SMARCA2 Degraders
Educational Video Series