Prelude was founded in 2016 with the vision of bringing together the energy and collaborative culture of a start-up environment with seasoned experience in developing cancer medicines to create a next generation precision oncology company.

Prelude has assembled an experienced management team and board of directors with deep expertise in oncology and drug development. We have built from the “ground up” our internal discovery engine led by scientific and medical teams with proven capabilities in inventing and rapidly developing small molecule medicines that have the potential to transform cancer care.

deborah-morosini

Deborah Morosini, M.D., M.S.W.

Executive Vice President and Chief of Clinical Affairs

Deborah Morosini, M.D., M.S.W. joined Prelude Therapeutics in 2020 and currently serves as Executive Vice President and Chief of Clinical Affairs. She brings to Prelude extensive expertise in oncology drug development, clinical genomics, and philanthropic activism. She previously served as Vice President of Clinical Affairs and Patient Engagement (Chief Patient Officer) at Loxo Oncology, where she built and led patient engagement and enrollment strategy, medical affairs, and patient advocacy. Dr. Morosini played a key role in the launch of Vitrakvi® (larotrectinib) via a co-promote partnership with Bayer, and conducted launch preparations for LOXO-292, a RET inhibitor for lung and thyroid cancer. Prior to Loxo, she was an early team member at Foundation Medicine, where she developed a niche specialty in the genomics of adolescent and young adult cancer. Before joining Foundation Medicine, she founded and led the molecular pathology group at AstraZeneca Pharmaceuticals, where she helped develop and implement biomarker strategies for biomarker-driven trials. Prior to AstraZeneca, Dr. Morosini served as Director of Pathology for Ardais, a clinical genomics biotechnology company. She has been featured as a spokesperson for numerous non-profit and government events in oncology and has provided expert commentary for national broadcast media. She has served on numerous national oncology non-profit boards, and currently serves on the Board of Directors for ClinWiki and the SAB for Target Cancer and Upstage Lung Cancer. Dr. Morosini earned her B.A. in English from Mount Holyoke College, her M.S.W. from NYU Graduate School of Social Work, and her M.D. from Boston University School of Medicine. She completed a pathology residency at Boston Medical Center.

Board of Directors

Paul Friedman, M.D. was appointed to the Board of Directors in July 2016. He currently serves as Chairman and Chief Executive Office of Madrigal Pharmaceuticals. Dr. Friedman previously served as the Chief Executive Officer and a Director of Incyte Corporation from 2001 until his retirement in 2014. From 1994 to 1998, he served as President of Research & Development for the DuPont-Merck Pharmaceutical Company; and from 1998 to 2001 as President of DuPont Pharmaceuticals Research Laboratories, a wholly-owned subsidiary of the DuPont Company. From 1991 to 1994, he served as Senior Vice President at Merck Research Laboratories. Prior to his tenures at Merck and DuPont, Dr. Friedman was an Associate Professor of Medicine and Pharmacology at Harvard Medical School. He is a diplomat of the American Board of Internal Medicine and a member of the American Society of Clinical Investigation. Dr. Friedman currently serves on the boards of directors of Incyte Corporation, Alexion Pharmaceuticals, Inc. and Madrigal Pharmaceuticals, Inc. He has previously served on the boards of directors of Cerulean Pharma Inc. and Verastem, Inc. Dr. Friedman received his A.B. in Biology from Princeton University and his M.D. from Harvard Medical School.

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David Bonita, M.D., has been a member of Prelude’s Board of Directors since July 2016. Since June 2014, Dr. Bonita has served in various roles at OrbiMed Advisors LLC. Dr. Bonita currently serves on the boards of directors of a number of public and private companies. He has also worked as a Corporate Finance Analyst in the healthcare investment banking groups of Morgan Stanley and UBS. He received his A.B. in Biological Sciences from Harvard University and his joint M.D./M.B.A. from Columbia University.

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Julian C. Baker joined the Prelude Board of Directors in January 2021. Mr. Baker is a Managing Member of Baker Brothers Investments a biotechnology-focused investment adviser to fund partnerships whose investors are primarily endowments and foundations, which Mr. Baker founded, together with his brother Felix Baker, in 2000. Prior to Baker Brothers, Mr. Baker was a portfolio manager at Tisch Financial Management from 1994 to 1999. Previously, Mr. Baker was employed from 1988 to 1993 by the private equity investment arm of Credit Suisse First Boston Corporation. Mr. Baker holds an A.B. from Harvard University. He serves on the boards of Incyte Corporation, Acadia Pharmaceuticals, Inc., Prelude Therapeutics, Inc., and Everyone Medicines Inc.  

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Kris Vaddi, Ph.D. founded Prelude Therapeutics and has served as the Chief Executive Officer and member of the Board of Directors since 2016. Prior to founding Prelude, from 2014 to 2016, Dr. Vaddi served as Chief Executive Officer of Orsenix, LLC, a clinical stage biotechnology company. Previously, he held several roles at Incyte Corporation, starting as a Founding Scientist and an Executive Director in 2002, and most recently as a Senior Advisor from 2015 to 2016. Dr. Vaddi initiated and championed JAK research programs at Incyte that led to the discovery, development, and approval of Jakafi® (ruxolotinib) for Myelofibrosis and Polycythemia Vera and Olumiant® (baricitinib) for rheumatoid arthritis. He received his BVSc in Veterinary Medicine from APAU in India and his Ph.D. in Pharmacology and Toxicology from University of Florida.

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Mardi C. Dier has served as a member of Prelude’s Board of Directors since August 2020. Ms. Dier currently serves as the Chief Financial Officer of Ultragenyx. She previously  served as Executive Vice President and Chief Financial Officer, and also as Chief Business Officer, of Portola Pharmaceuticals, Inc., a biopharmaceutical company, from November 2013 and October 2018, respectively, until its acquisition by Alexion Pharmaceuticals in July 2020, and as a Senior Vice President and Chief Financial Officer from August 2006 to November 2013. From 2003 to 2006, Ms. Dier served as Vice President of Investor Relations at Chiron Corporation, a biopharmaceutical company. From 1994 to 2001, Ms. Dier served as a Director, Investment Banking at Prudential Securities, Inc., a securities firm. Ms. Dier previously served as a supervising senior accountant at the audit department of KPMG Peat Marwick, an accounting firm, from 1986 to 1990. Ms. Dier currently serves as a director, and member of the audit committee, of Adamas Pharmaceuticals, Inc., a biopharmaceutical company, and as a director of Oric Pharmaceuticals, Inc. Ms. Dier received a B.S. in Biology from Stanford University and an M.B.A. from the Anderson Graduate School of Management at the University of California, Los Angeles. 

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Victor Sandor has served as a member of Prelude’s Board of Directors since May 2020. From September 2014 to December 2019, Dr. Sandor served as the Chief Medical Officer at Array BioPharma Inc., a pharmaceutical company. From September 2010 to June 2014, he served as the Senior Vice President for Global Clinical Development at Incyte Corporation, a pharmaceutical company. Dr. Sandor also previously served as Vice President and Chief Medical Officer for Oncology at Biogen Idec and held positions of increasing responsibility in oncology product development at AstraZeneca. Dr. Sandor has served on the board of directors of ADC Therapeutics SA since April 2020 and Merus N.V. since June 2019. Dr. Sandor received a M.D.C.M. from McGill University in Montreal, Canada, and completed his Fellowship in Medical Oncology at the National Institutes of Health in Bethesda, Maryland. 

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