Prelude’s lead product candidates, PRT543 and PRT811, are designed to be oral, potent, and selective PRMT5 inhibitors.

PRT543, Prelude’s first clinical product candidate, is designed to be a potent, selective, and oral PRMT5 inhibitor with dose-dependent pharmacodynamics (PD) and predictable pharmacokinetics (PK). PRT543 has demonstrated preclinical activity both as a single agent and in combination therapy.

PRT543 is being studied in a Phase 1 clinical trial in advanced solid tumors and select myeloid malignancies, including adenoid cystic carcinoma (ACC), myelofibrosis (MF), genomically-selected myelodysplastic syndrome (MDS), and homologous recombination deficient (HRD+) tumors.

PRT543 Graphic