Discovery of First-in-Class Calreticulin-targeted Degrader Antibody Conjugates Delivering a CDK9 Degrader Payload for the Treatment of CALR-mutated MPNs

Norman Fultang1, Ashley Schwab1, Sharayu Chandratre1, Jake Karwoski1, Grace Davis1, Ian Johnson1, Neha Bhagwat1, Yue Zou1, Arpita Mondal1, Max Foroutan1, Min Wang1, Andrew Buesking1, Chun Chen1, Corey Basch1, Ryan Holmes1, Sang Hyun Lee1, Diane Heiser1, Andrew Combs1, Peggy Scherle1