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PRT2527 (CDK9)

PRT2527 is designed to be a potent and selective CDK9 inhibitor.

Prelude is developing PRT2527, which is designed to be a potent and selective CDK9 inhibitor. PRT2527 was shown to reduce MCL1 and MYC protein levels and was highly active in preclinical models at well-tolerated doses. PRT2527 has demonstrated high potency and kinase selectivity which may offer improved efficacy and safety compared to less selective CDK9 inhibitors.